| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PES1 |
| Gene ID: | 23481 |
| Uniprot ID: | PESC_HUMAN |
| Immunogen Region: | 1-150 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PES1 (NP_055118.1). |
| Immunogen Sequence: | MGGLEKKKYERGSATNYITR NKARKKLQLSLADFRRLCIL KGIYPHEPKHKKKVNKGSTA ARTFYLIKDIRFLLHEPIVN KFREYKVFVRKLRKAYGKSE WNTVERLKDNKPNYKLDHII KERYPTFIDALRDLDDALSM CFLFSTFPRT |
| Tissue Specificity | Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin. |
| Post Translational Modifications | Sumoylated. |
| Function | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
| Protein Name | Pescadillo Homolog |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusNucleoplasmChromosomeAppears To Localize To The Periphery Of Metaphase Chromosomes During Mitosis And To The Prenucleolar Bodies That Form In Mitotic Cells Prior To The Actual Nucleoli |
| Alternative Antibody Names | Anti-Pescadillo Homolog antibodyAnti-PES1 antibody |
Information sourced from Uniprot.org