• Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using PPHLN Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from COLO and 293 cells, using PPHLN Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Periphilin 1 Polyclonal Antibody

Anti-PPHLN1 antibody (71-120 aa) (STJ95030)

SKU:
STJ95030

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Periphilin-1 (71-120 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PPHLN1
Gene ID: 51535
Uniprot ID: PPHLN_HUMAN
Immunogen Region: 71-120 aa
Specificity: Periphilin 1 Polyclonal Antibody detects endogenous levels of Periphilin 1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human PPHLN at the amino acid range 71-120
Post Translational Modifications Substrate of transglutaminase (in vitro).
Function Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin. Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation.
Protein Name Periphilin-1
Cdc7 Expression Repressor
Cr
Gastric Cancer Antigen Ga50
Cellular Localisation Nucleus
Cytoplasm
Chromosome
In Undifferentiated Keratinocytes Expressed In Speckle-Type Nuclear Granules And At The Nuclear Membrane
But In The Differentiated Keratinocytes Colocalized With Periplakin At The Cell Periphery And At Cell-Cell Junctions
Localizes To Chromatin
Alternative Antibody Names Anti-Periphilin-1 antibody
Anti-Cdc7 Expression Repressor antibody
Anti-Cr antibody
Anti-Gastric Cancer Antigen Ga50 antibody
Anti-PPHLN1 antibody
Anti-HSPC206 antibody
Anti-HSPC232 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance