| Tissue Specificity | Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression. |
| Function | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. |
| Protein Name | Pdz And Lim Domain Protein 5Enigma HomologEnigma-Like Pdz And Lim Domains Protein |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Postsynaptic DensityPresynapsePostsynapseCytoplasmCytosolDetected Both At Presynaptic And Postsynaptic SitesExclusively At Excitatory SynapsesBut Not Inhibitory SynapsesIn Hippocampal Neurons |
| Alternative Antibody Names | Anti-Pdz And Lim Domain Protein 5 antibodyAnti-Enigma Homolog antibodyAnti-Enigma-Like Pdz And Lim Domains Protein antibodyAnti-PDLIM5 antibodyAnti-ENH antibodyAnti-L9 antibody |
Information sourced from Uniprot.org
