| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Platelet-Derived Growth Factor Subunit B (142-241) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4676RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDGFB |
| Gene ID: |
5155 |
| Uniprot ID: |
PDGFB_HUMAN |
| Immunogen Region: |
142-241 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 142-241 of human PDGFB (NP_002599.1). |
| Immunogen Sequence: |
RPTQVQLRPVQVRKIEIVRK KPIFKKATVTLEDHLACKCE TVAAARPVTRSPGGSQEQRA KTPQTRVTIRTVRVRRPPKG KHRKFKHTHDKTALKETLGA |
| Tissue Specificity | Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung. |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. |
| Protein Name | Platelet-Derived Growth Factor Subunit BPdgf Subunit BPdgf-2Platelet-Derived Growth Factor B ChainPlatelet-Derived Growth Factor Beta PolypeptideProto-Oncogene C-SisBecaplermin |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1257604Reactome: R-HSA-186763Reactome: R-HSA-186797Reactome: R-HSA-2219530Reactome: R-HSA-3000171Reactome: R-HSA-5673001Reactome: R-HSA-6811558 |
| Cellular Localisation | SecretedReleased By Platelets Upon Wounding |
| Alternative Antibody Names | Anti-Platelet-Derived Growth Factor Subunit B antibodyAnti-Pdgf Subunit B antibodyAnti-Pdgf-2 antibodyAnti-Platelet-Derived Growth Factor B Chain antibodyAnti-Platelet-Derived Growth Factor Beta Polypeptide antibodyAnti-Proto-Oncogene C-Sis antibodyAnti-Becaplermin antibodyAnti-PDGFB antibodyAnti-PDGF2 antibodyAnti-SIS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
