| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PDE1C (435-634) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDE1C |
| Gene ID: |
5137 |
| Uniprot ID: |
PDE1C_HUMAN |
| Immunogen Region: |
435-634 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 435-634 of human PDE1C (NP_001177985.1). |
| Immunogen Sequence: |
VEPTFTVLTDMTEKIVSPLI DETSQTGGTGQRRSSLNSIS SSDAKRSGVKTSGSEGSAPI NNSVISVDYKSFKATWTEVV HINRERWRAKVPKEEKAKKE AEEKARLAAEEQQKEMEAKS QAEEGASGKAEKKTSGETKN QVNGTRANKSDNPRGKNSKA EKSSGEQQQNGDFKDGKNKT DKKDHSNIGNDSKKTDDSQE |
| Tissue Specificity | Isoform PDE1C2 is present in the heart and brain and, at lower levels in the lung, liver, kidney and skeletal muscle. Isoform PDE1C1 is expressed in the heart and brain and, at lower levels in lung. Also expressed at low levels in uterus and testis. |
| Function | Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). |
| Protein Name | Dual Specificity Calcium/Calmodulin-Dependent 3' -5'-Cyclic Nucleotide Phosphodiesterase 1cCam-Pde 1cHcam3 |
| Database Links | Reactome: R-HSA-111957 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Dual Specificity Calcium/Calmodulin-Dependent 3' -5'-Cyclic Nucleotide Phosphodiesterase 1c antibodyAnti-Cam-Pde 1c antibodyAnti-Hcam3 antibodyAnti-PDE1C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] NBS1/NBS1/NBN Rabbit polyclonal antibody (STJ114898) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/93967/375277/STJ114898_1__01767.1713142004.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] NBS1/NBS1/NBN Rabbit polyclonal antibody (STJ114898) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
