| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PCSK5 (601-913) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PCSK5 |
| Gene ID: |
5125 |
| Uniprot ID: |
PCSK5_HUMAN |
| Immunogen Region: |
601-913 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 601-913 of human PCSK5 (NP_006191.2). |
| Immunogen Sequence: |
QPYSPTNEFPKVERFRYSRV EDPTDDYGTEDYAGPCDPEC SEVGCDGPGPDHCNDCLHYY YKLKNNTRICVSSCPPGHYH ADKKRCRKCAPNCESCFGSH GDQCMSCKYGYFLNEETNSC VTHCPDGSYQDTKKNLCRKC SENCKTCTEFHNCTECRDGL SLQGSRCSVSCEDGRYFNGQ DCQPCHRFCATCAGAGADGC INCTEGYFMEDGRCVQSCSI SYYFDHSSENGYKSCKKCD |
| Tissue Specificity | Expressed in T-lymphocytes. |
| Function | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXXKRR consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. |
| Protein Name | Proprotein Convertase Subtilisin/Kexin Type 5Proprotein Convertase 5Pc5Proprotein Convertase 6Pc6Hpc6Subtilisin/Kexin-Like Protease Pc5 |
| Database Links | Reactome: R-HSA-167060Reactome: R-HSA-8963889 |
| Cellular Localisation | Isoform Pc6a: SecretedSecreted Through The Regulated Secretory PathwayIsoform Pc6b: Endomembrane SystemSingle-Pass Type I Membrane ProteinType I Membrane Protein Localized To A Paranuclear Post-Golgi Network Compartment In Communication With Early Endosomes |
| Alternative Antibody Names | Anti-Proprotein Convertase Subtilisin/Kexin Type 5 antibodyAnti-Proprotein Convertase 5 antibodyAnti-Pc5 antibodyAnti-Proprotein Convertase 6 antibodyAnti-Pc6 antibodyAnti-Hpc6 antibodyAnti-Subtilisin/Kexin-Like Protease Pc5 antibodyAnti-PCSK5 antibodyAnti-PC5 antibodyAnti-PC6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
