| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PCGF2 (115-241) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PCGF2 |
| Gene ID: |
7703 |
| Uniprot ID: |
PCGF2_HUMAN |
| Immunogen Region: |
115-241 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 115-241 of human PCGF2 (NP_009075.1). |
| Immunogen Sequence: |
GEVLEQEKGALSDDEIVSLS IEFYEGARDRDEKKGPLENG DGDKEKTGVRFLRCPAAMTV MHLAKFLRNKMDVPSKYKVE VLYEDEPLKEYYTLMDIAYI YPWRRNGPLPLKYRVQPACK RLTLATV |
| Tissue Specificity | Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle. |
| Post Translational Modifications | Phosphorylated. Homodimer formation is regulated by phosphorylation with only unphosphorylated proteins forming homodimers. |
| Function | Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. |
| Protein Name | Polycomb Group Ring Finger Protein 2Dna-Binding Protein Mel-18Ring Finger Protein 110Zinc Finger Protein 144 |
| Database Links | Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-5617472Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Polycomb Group Ring Finger Protein 2 antibodyAnti-Dna-Binding Protein Mel-18 antibodyAnti-Ring Finger Protein 110 antibodyAnti-Zinc Finger Protein 144 antibodyAnti-PCGF2 antibodyAnti-MEL18 antibodyAnti-RNF110 antibodyAnti-ZNF144 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
