| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PCDH8 |
| Gene ID: | 5100 |
| Uniprot ID: | PCDH8_HUMAN |
| Immunogen Region: | 450-750 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-750 of human PCDH8 (NP_002581.2). |
| Immunogen Sequence: | VTAASLDRERIAEYNLTLVA EDRGAPPLRTVRPYTVRVGD ENDNAPLFTRPVYEVSVREN NPPGAYLATVAARDRDLGRN GQVTYRLLEAEVGRAGGAVS TYVSVDPATGAIYALRSFDY ETLRQLDVRIQASDGGSPQL SSSALVQVRVLDQNDHAPVL VHPAPANGSLEVAVPGRTAK DTVVARVQARDADEGANGEL AFELQQQEPREAFAIGRRTG EILLTGDLSQEPPGRVFRA |
| Function | Calcium-dependent cell-adhesion protein. May play a role in activity-induced synaptic reorganization underlying long term memory. Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis. |
| Protein Name | Protocadherin-8 Arcadlin |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cell Projection Dendrite Presynaptic Cell Membrane Postsynaptic Cell Membrane Also Expressed In Neuronal Cell Bodies Localized To Excitatory But Not With Inhibitory Synapses |
| Alternative Antibody Names | Anti-Protocadherin-8 antibody Anti-Arcadlin antibody Anti-PCDH8 antibody |
Information sourced from Uniprot.org