• Western blot analysis of various lysates using PCDH8 Rabbit polyclonal antibody (STJ116463) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-PCDH8 antibody (450-750) (STJ116463)

SKU:
STJ116463

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PCDH8 (450-750) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PCDH8
Gene ID: 5100
Uniprot ID: PCDH8_HUMAN
Immunogen Region: 450-750
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 450-750 of human PCDH8 (NP_002581.2).
Immunogen Sequence: VTAASLDRERIAEYNLTLVA EDRGAPPLRTVRPYTVRVGD ENDNAPLFTRPVYEVSVREN NPPGAYLATVAARDRDLGRN GQVTYRLLEAEVGRAGGAVS TYVSVDPATGAIYALRSFDY ETLRQLDVRIQASDGGSPQL SSSALVQVRVLDQNDHAPVL VHPAPANGSLEVAVPGRTAK DTVVARVQARDADEGANGEL AFELQQQEPREAFAIGRRTG EILLTGDLSQEPPGRVFRA
Function Calcium-dependent cell-adhesion protein. May play a role in activity-induced synaptic reorganization underlying long term memory. Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis.
Protein Name Protocadherin-8
Arcadlin
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Dendrite
Presynaptic Cell Membrane
Postsynaptic Cell Membrane
Also Expressed In Neuronal Cell Bodies
Localized To Excitatory
But Not With Inhibitory
Synapses
Alternative Antibody Names Anti-Protocadherin-8 antibody
Anti-Arcadlin antibody
Anti-PCDH8 antibody

Information sourced from Uniprot.org

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