| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein PAXX is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAXX |
| Gene ID: |
286257 |
| Uniprot ID: |
PAXX_HUMAN |
| Specificity: |
This antibody detects endogenous levels of C9orf142 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human C9orf142 |
| Function | Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ).participates in double-strand break (DSB) repair and V(D)J recombination. May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery. Involved in NHEJ by promoting the ligation of blunt-ended DNA ends. Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends. Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair. Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism. |
| Protein Name | Protein PaxxParalog Of Xrcc4 And XlfXrcc4-Like Small Protein |
| Cellular Localisation | NucleusChromosomePredominantly Localizes To The NucleusAccumulates At Sites Of Dna Damage Generated By Laser MicroirradiationCytoplasm(Microbial Infection) Upon Infection By Herpesvirus 1 (Hsv-1)It Is Partially Translocated Into The Cytoplasm In An Hsv-1-Dependent Manner |
| Alternative Antibody Names | Anti-Protein Paxx antibodyAnti-Paralog Of Xrcc4 And Xlf antibodyAnti-Xrcc4-Like Small Protein antibodyAnti-PAXX antibodyAnti-C9orf142 antibodyAnti-XLS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
