• Western blot analysis of extracts of various cell lines, using PATL1 antibody (STJ115136) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-PATL1 antibody (535-640) (STJ115136)

SKU:
STJ115136

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PATL1 (535-640) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PATL1
Gene ID: 219988
Uniprot ID: PATL1_HUMAN
Immunogen Region: 535-640
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 535-640 of human PATL1 (NP_689929.2).
Immunogen Sequence: DVEDYERRYLLSLEEERPAL MDDRKHKICSMYDNLRGKLP GQERPSDDHFVQIMCIRKGK RMVARILPFLSTEQAADILM TTARNLPFLIKKDAQDEVLP CLLSPF
Tissue Specificity Ubiquitous.
Function RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV).
Protein Name Protein Pat1 Homolog 1
Pat1-Like Protein 1
Protein Pat1 Homolog B
Pat1b
Hpat1b
Database Links Reactome: R-HSA-430039
Cellular Localisation Cytoplasm
P-Body
Nucleus
Pml Body
Nucleus Speckle
Predominantly Cytoplasmic
Shuttles Between The Nucleus And The Cytoplasm In A Crm1-Dependent Manner
Enriched In Splicing Speckles
Localization To Nuclear Foci And Speckles Requires Active Transcription
Excluded From The Nucleolus
Alternative Antibody Names Anti-Protein Pat1 Homolog 1 antibody
Anti-Pat1-Like Protein 1 antibody
Anti-Protein Pat1 Homolog B antibody
Anti-Pat1b antibody
Anti-Hpat1b antibody
Anti-PATL1 antibody
Anti-OK antibody
Anti-KNS-cl.5 antibody

Information sourced from Uniprot.org

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