| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PARD6B |
| Gene ID: | 84612 |
| Uniprot ID: | PAR6B_HUMAN |
| Immunogen Region: | 253-372 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 253-372 of human PARD6B (NP_115910.1). |
| Immunogen Sequence: | NNVVRNSRTSGSSGQSTDNS LLGYPQQIEPSFEPEDEDSE EDDIIIEDNGVPQQIPKAVP NTESLESLTQIELSFESGQN GFIPSNEVSLAAIASSSNTE FETHAPDQKLLEEDGTIITL |
| Tissue Specificity | Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues. |
| Function | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. |
| Protein Name | Partitioning Defective 6 Homolog BetaPar-6 BetaPar-6b |
| Database Links | Reactome: R-HSA-420029Reactome: R-HSA-9013424 |
| Cellular Localisation | CytoplasmCell MembraneCell JunctionTight Junction |
| Alternative Antibody Names | Anti-Partitioning Defective 6 Homolog Beta antibodyAnti-Par-6 Beta antibodyAnti-Par-6b antibodyAnti-PARD6B antibodyAnti-PAR6B antibody |
Information sourced from Uniprot.org