| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PARD6B (253-372) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:4000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PARD6B |
| Gene ID: |
84612 |
| Uniprot ID: |
PAR6B_HUMAN |
| Immunogen Region: |
253-372 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 253-372 of human PARD6B (NP_115910.1). |
| Immunogen Sequence: |
NNVVRNSRTSGSSGQSTDNS LLGYPQQIEPSFEPEDEDSE EDDIIIEDNGVPQQIPKAVP NTESLESLTQIELSFESGQN GFIPSNEVSLAAIASSSNTE FETHAPDQKLLEEDGTIITL |
| Tissue Specificity | Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues. |
| Function | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. |
| Protein Name | Partitioning Defective 6 Homolog BetaPar-6 BetaPar-6b |
| Database Links | Reactome: R-HSA-420029Reactome: R-HSA-9013424 |
| Cellular Localisation | CytoplasmCell MembraneCell JunctionTight Junction |
| Alternative Antibody Names | Anti-Partitioning Defective 6 Homolog Beta antibodyAnti-Par-6 Beta antibodyAnti-Par-6b antibodyAnti-PARD6B antibodyAnti-PAR6B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
