| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAFAH1B2 (1-229) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAFAH1B2 |
| Gene ID: |
5049 |
| Uniprot ID: |
PA1B2_HUMAN |
| Immunogen Region: |
1-229 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human PAFAH1B2 (NP_002563.1). |
| Immunogen Sequence: |
MSQGDSNPAAIPHAAEDIQG DDRWMSQHNRFVLDCKDKEP DVLFVGDSMVQLMQQYEIWR ELFSPLHALNFGIGGDTTRH VLWRLKNGELENIKPKVIVV WVGTNNHENTAEEVAGGIEA IVQLINTRQPQAKIIVLGLL PRGEKPNPLRQKNAKVNQLL KVSLPKLANVQLLDTDGGFV HSDGAISCHDMFDFLHLTGG GYAKICKPLHELIMQLLEET PEEKQTTIA |
| Tissue Specificity | Ubiquitous. |
| Function | Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis. |
| Protein Name | Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha2Paf Acetylhydrolase 30 Kda SubunitPaf-Ah 30 Kda SubunitPaf-Ah Subunit BetaPafah Subunit Beta |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6811436 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha2 antibodyAnti-Paf Acetylhydrolase 30 Kda Subunit antibodyAnti-Paf-Ah 30 Kda Subunit antibodyAnti-Paf-Ah Subunit Beta antibodyAnti-Pafah Subunit Beta antibodyAnti-PAFAH1B2 antibodyAnti-PAFAHB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
