Anti-PAEP antibody (19-180) (STJ116957)

SKU:
STJ116957

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Host: Rabbit
Applications: IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PAEP (19-180) is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PAEP
Gene ID: 5047
Uniprot ID: PAEP_HUMAN
Immunogen Region: 19-180
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-180 of human PAEP (NP_002562.2).
Immunogen Sequence: MDIPQTKQDLELPKLAGTWH SMAMATNNISLMATLKAPLR VHITSLLPTPEDNLEIVLHR WENNSCVEKKVLGEKTENPK KFKINYTVANEATLLDTDYD NFLFLCLQDTTTPIQSMMCQ YLARVLVEDDEIMQGFIRAF RPLPRHLWYLLDLKQMEEPC RF
Tissue Specificity This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy. Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level). Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level). Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level). Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling.
Post Translational Modifications Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C.
Function Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa.
Protein Name Glycodelin
Gd
Placental Protein 14
Pp14
Pregnancy-Associated Endometrial Alpha-2 Globulin
Paeg
Peg
Progestagen-Associated Endometrial Protein
Progesterone-Associated Endometrial Protein
Zona-Binding Inhibitory Factor-1
Zif-1
Cellular Localisation Secreted
Alternative Antibody Names Anti-Glycodelin antibody
Anti-Gd antibody
Anti-Placental Protein 14 antibody
Anti-Pp14 antibody
Anti-Pregnancy-Associated Endometrial Alpha-2 Globulin antibody
Anti-Paeg antibody
Anti-Peg antibody
Anti-Progestagen-Associated Endometrial Protein antibody
Anti-Progesterone-Associated Endometrial Protein antibody
Anti-Zona-Binding Inhibitory Factor-1 antibody
Anti-Zif-1 antibody
Anti-PAEP antibody

Information sourced from Uniprot.org

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