| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | P2RY4 |
| Gene ID: | 5030 |
| Uniprot ID: | P2RY4_HUMAN |
| Immunogen Region: | 286-365 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 286-365 of human P2RY4 (NP_002556.1). |
| Immunogen Sequence: | VVYKVTRPLASANSCLDPVL YLLTGDKYRRQLRQLCGGGK PQPRTAASSLALVSLPEDSS CRWAATPQDSSCSTPRADRL |
| Tissue Specificity | Pancreas. |
| Post Translational Modifications | Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases. |
| Function | Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP. |
| Protein Name | P2y Purinoceptor 4P2y4P2pUridine Nucleotide ReceptorUnr |
| Database Links | Reactome: R-HSA-417957Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-P2y Purinoceptor 4 antibodyAnti-P2y4 antibodyAnti-P2p antibodyAnti-Uridine Nucleotide Receptor antibodyAnti-Unr antibodyAnti-P2RY4 antibodyAnti-NRU antibody |
Information sourced from Uniprot.org