| Host: | Rabbit |
| Applications: | WB/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | OTUD6B |
| Gene ID: | 51633 |
| Uniprot ID: | OTU6B_HUMAN |
| Immunogen Region: | 31-323 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-323 of human OTUD6B (NP_057107.3). |
| Immunogen Sequence: | MEAVLTEELDEEEQLLRRHR KEKKELQAKIQGMKNAVPKN DKKRRKQLTEDVAKLEKEME QKHREELEQLKLTTKENKID SVAVNISNLVLENQPPRISK AQKRREKKAALEKEREERIA EAEIENLTGARHMESEKLAQ ILAARQLEIKQIPSDGHCMY KAIEDQLKEKDCALTVVALR SQTAEYMQSHVEDFLPFLTN PNTGDMYTPEEFQKYCEDIV NTAAWGGQLELRALSHILQ |
| Function | Isoform 1: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1. May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation. May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation. May also play a role in proteasome assembly and function. Isoform 2: Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability. |
| Protein Name | Deubiquitinase Otud6bDuba-5Otu Domain-Containing Protein 6b |
| Alternative Antibody Names | Anti-Deubiquitinase Otud6b antibodyAnti-Duba-5 antibodyAnti-Otu Domain-Containing Protein 6b antibodyAnti-OTUD6B antibodyAnti-DUBA5 antibodyAnti-CGI-77 antibody |
Information sourced from Uniprot.org