| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ERCC1 (1-323) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ERCC1 |
| Gene ID: |
2067 |
| Uniprot ID: |
ERCC1_HUMAN |
| Immunogen Region: |
1-323 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human ERCC1 (NP_973730.1). |
| Immunogen Sequence: |
MDPGKDKEGVPQPSGPPARK KFVIPLDEDEVPPGVAKPLF RSTQSLPTVDTSAQAAPQTY AEYAISQPLEGAGATCPTGS EPLAGETPNQALKPGAKSNS IIVSPRQRGNPVLKFVRNVP WEFGDVIPDYVLGQSTCALF LSLRYHNLHPDYIHGRLQSL GKNFALRVLLVQVDVKDPQQ ALKELAKMCILADCTLILAW SPEEAGRYLETYKAYEQKPA DLLMEKLEQDFVSRVTECL |
| Post Translational Modifications | Ubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Deubiquitinated by USP45. |
| Function | Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. Isoform 2: Not functional in the nucleotide excision repair pathway. Isoform 3: Not functional in the nucleotide excision repair pathway. Isoform 4: Not functional in the nucleotide excision repair pathway. |
| Protein Name | Dna Excision Repair Protein Ercc-1 |
| Database Links | Reactome: R-HSA-5685938Reactome: R-HSA-5696395Reactome: R-HSA-5696400Reactome: R-HSA-6782135Reactome: R-HSA-6783310 |
| Cellular Localisation | Isoform 1: NucleusIsoform 2: CytoplasmNucleusIsoform 3: NucleusIsoform 4: Nucleus |
| Alternative Antibody Names | Anti-Dna Excision Repair Protein Ercc-1 antibodyAnti-ERCC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
