| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-OS9 (353-612) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OS9 |
| Gene ID: |
10956 |
| Uniprot ID: |
OS9_HUMAN |
| Immunogen Region: |
353-612 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 353-612 of human OS9 (NP_001017956.1). |
| Immunogen Sequence: |
NVQVKVIRSPADLIRFIEEL KGGTKKGKPNIGQEQPVDDA AEVPQREPEKERGDPERQRE MEEEEDEDEDEDEDEDERQL LGEFEKELEGILLPSDRDRL RSEVKAGMERELENIIQETE KELDPDGLKKESERDRAMLA LTSTLNKLIKRLEEKQSPEL VKKHKKKRVVPKKPPPSPQP TGKIEIKIVRPWAEGTEEGA RWLTDEDTRNLKEIFFNILV PGAEEAQKERQRQKELESN |
| Tissue Specificity | Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined. |
| Post Translational Modifications | Intramolecular disulfide bonds. Isoform 1 and isoform 2 are N-glycosylated. |
| Function | Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. |
| Protein Name | Protein Os-9Amplified In Osteosarcoma 9 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5358346Reactome: R-HSA-5362768Reactome: R-HSA-5678895Reactome: R-HSA-901032 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Protein Os-9 antibodyAnti-Amplified In Osteosarcoma 9 antibodyAnti-OS9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
