| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ORC5 (220-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ORC5 |
| Gene ID: |
5001 |
| Uniprot ID: |
ORC5_HUMAN |
| Immunogen Region: |
220-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 220-350 of human ORC5 (NP_002544.1). |
| Immunogen Sequence: |
RDLKELRHLAVLNFPKYCEP VVKGEASERDTRKLWRNIEP HLKKAMQTVYLREISSSQWE KLQKDDTDPGQLKGLSAHTH VELPYYSKFILIAAYLASYN PARTDKRFFLKHHGKIKKTN FLKKHEKTSNH |
| Tissue Specificity | Abundant in spleen, ovary, prostate, testis, and colon mucosa. |
| Post Translational Modifications | Multi-mono-ubiquitinated by OBI1.ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle. |
| Function | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Protein Name | Origin Recognition Complex Subunit 5 |
| Database Links | Reactome: R-HSA-113507Reactome: R-HSA-176187Reactome: R-HSA-68616Reactome: R-HSA-68689Reactome: R-HSA-68867Reactome: R-HSA-68949Reactome: R-HSA-68962 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Origin Recognition Complex Subunit 5 antibodyAnti-ORC5 antibodyAnti-ORC5L antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
