| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NPR1 |
| Gene ID: | 4881 |
| Uniprot ID: | ANPRA_HUMAN |
| Immunogen Region: | 260-470 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-470 of human NPR1 (NP_000897.3). |
| Immunogen Sequence: | EAGLCGEDYVFFHLDIFGQS LQGGQGPAPRRPWERGDGQD VSARQAFQAAKIITYKDPDN PEYLEFLKQLKHLAYEQFNF TMEDGLVNTIPASFHDGLLL YIQAVTETLAHGGTVTDGEN ITQRMWNRSFQGVTGYLKID SSGDRETDFSLWDMDPENGA FRVVLNYNGTSQELVAVSGR KLNWPLGYPPPDIPKCGFDN EDPACNQDHLS |
| Post Translational Modifications | Phosphorylation of the protein kinase-like domain is required for full activation by ANP. |
| Function | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. |
| Protein Name | Atrial Natriuretic Peptide Receptor 1Atrial Natriuretic Peptide Receptor Type AAnp-AAnpr-ANpr-AGuanylate Cyclase AGc-A |
| Database Links | Reactome: R-HSA-5578768 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Atrial Natriuretic Peptide Receptor 1 antibodyAnti-Atrial Natriuretic Peptide Receptor Type A antibodyAnti-Anp-A antibodyAnti-Anpr-A antibodyAnti-Npr-A antibodyAnti-Guanylate Cyclase A antibodyAnti-Gc-A antibodyAnti-NPR1 antibodyAnti-ANPRA antibody |
Information sourced from Uniprot.org