| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NPL (1-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NPL |
| Gene ID: |
80896 |
| Uniprot ID: |
NPL_HUMAN |
| Immunogen Region: |
1-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human NPL (NP_110396.1). |
| Immunogen Sequence: |
MAFPKKKLQGLVAATITPMT ENGEINFSVIGQYVDYLVKE QGVKNIFVNGTTGEGLSLSV SERRQVAEEWVTKGKDKLDQ VIIHVGALSLKESQELAQHA AEIGADGIAVIAPFFLKPWT KDILINFLKEVAAAAPALPF YYYHIPALTGVKIRAEELLD GILDKIPTFQGLKFSDTDLL DFGQCVDQNRQQQFAFLFGV DEQLLSALVMGATGAVGSTY NYLGKKTNQMLEAFEQKDF |
| Tissue Specificity | Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte. |
| Function | Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (Probable). |
| Protein Name | N-Acetylneuraminate LyaseNalaseN-Acetylneuraminate Pyruvate-LyaseN-Acetylneuraminic Acid AldolaseSialate LyaseSialate-Pyruvate LyaseSialic Acid AldolaseSialic Acid Lyase |
| Database Links | Reactome: R-HSA-4085001 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-N-Acetylneuraminate Lyase antibodyAnti-Nalase antibodyAnti-N-Acetylneuraminate Pyruvate-Lyase antibodyAnti-N-Acetylneuraminic Acid Aldolase antibodyAnti-Sialate Lyase antibodyAnti-Sialate-Pyruvate Lyase antibodyAnti-Sialic Acid Aldolase antibodyAnti-Sialic Acid Lyase antibodyAnti-NPL antibodyAnti-C1orf13 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
