| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NOSTRIN |
| Gene ID: | 115677 |
| Uniprot ID: | NOSTN_HUMAN |
| Immunogen Region: | 270-430 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-430 of human NOSTRIN (NP_001034813.2). |
| Immunogen Sequence: | ILSTENKSEFLLTDYFEEDP NSAMDKERRKSLLKPKLLRL QRDIEKASKDKEGLERMLKT YSSTSSFSDAKSQKDTAALM DENNLKLDLLEANSYKLSSM LAELEQRPQPSHPCSNSIFR WREKEHTHSYVKISRPFLMK RLENIVSKASSGGQSNPGSS T |
| Tissue Specificity | Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level). |
| Function | Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. |
| Protein Name | NostrinBm247 HomologNitric Oxide Synthase Traffic InducerNitric Oxide Synthase TraffickerEnos-Trafficking Inducer |
| Database Links | Reactome: R-HSA-203641 |
| Cellular Localisation | Isoform 1: Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleCytoplasmCytoskeletonEnriched In Selected Actin StructuresIsoform 3: Nucleus |
| Alternative Antibody Names | Anti-Nostrin antibodyAnti-Bm247 Homolog antibodyAnti-Nitric Oxide Synthase Traffic Inducer antibodyAnti-Nitric Oxide Synthase Trafficker antibodyAnti-Enos-Trafficking Inducer antibodyAnti-NOSTRIN antibody |
Information sourced from Uniprot.org