Host: |
Rabbit |
Applications: |
WB/ELISA |
Reactivity: |
Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
Purification: |
Affinity purification |
Concentration: |
Lot specific |
Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
NME7 |
Gene ID: |
29922 |
Uniprot ID: |
NDK7_HUMAN |
Immunogen Region: |
1-376 |
Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-376 of human NME7 (NP_037462.1). |
Immunogen Sequence: |
MNHSERFVFIAEWYDPNASL LRRYELLFYPGDGSVEMHDV KNHRTFLKRTKYDNLHLEDL FIGNKVNVFSRQLVLIDYGD QYTARQLGSRKEKTLALIKP DAISKAGEIIEIINKAGFTI TKLKMMMLSRKEALDFHVDH QSRPFFNELIQFITTGPIIA MEILRDDAICEWKRLLGPAN SGVARTDASESIRALFGTDG IRNAAHGPDSFASAAREMEL FFPSSGGCGPANTAKFTNC |
Tissue Specificity | Expressed in airway epithelial cells. |
Post Translational Modifications | Undergoes autophosphorylation. |
Function | Possesses an intrinsic kinase activity. Displays 3'-5' exonuclease activity with a preference for single-stranded DNA. Does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of the microtubule-nucleating activity of the gamma-tubulin ring complex in centrosomes, in a kinase activity-dependent manner. Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. |
Protein Name | Nucleoside Diphosphate Kinase Homolog 7Ndk 7Ndp Kinase Homolog 73'-5' Exonuclease Nme7Protein Kinase Nme7Nm23-H7 |
Database Links | Reactome: R-HSA-380270Reactome: R-HSA-380320 |
Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusSpindleCilium AxonemeFlagellum AxonemeLocalizes To Centrosomes Through Its Assembly Into Gamma-Tubulin Ring ComplexThe Centrosomal Content Of Nme7 Varies During The Cell CycleBeing Highest In Mitosis And Lowest In Early G1 |
Alternative Antibody Names | Anti-Nucleoside Diphosphate Kinase Homolog 7 antibodyAnti-Ndk 7 antibodyAnti-Ndp Kinase Homolog 7 antibodyAnti-3'-5' Exonuclease Nme7 antibodyAnti-Protein Kinase Nme7 antibodyAnti-Nm23-H7 antibodyAnti-NME7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance