| Tissue Specificity | Expressed in airway epithelial cells. |
| Post Translational Modifications | Undergoes autophosphorylation. |
| Function | Possesses an intrinsic kinase activity. Displays 3'-5' exonuclease activity with a preference for single-stranded DNA. Does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of the microtubule-nucleating activity of the gamma-tubulin ring complex in centrosomes, in a kinase activity-dependent manner. Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. |
| Protein Name | Nucleoside Diphosphate Kinase Homolog 7Ndk 7Ndp Kinase Homolog 73'-5' Exonuclease Nme7Protein Kinase Nme7Nm23-H7 |
| Database Links | Reactome: R-HSA-380270Reactome: R-HSA-380320 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusSpindleCilium AxonemeFlagellum AxonemeLocalizes To Centrosomes Through Its Assembly Into Gamma-Tubulin Ring ComplexThe Centrosomal Content Of Nme7 Varies During The Cell CycleBeing Highest In Mitosis And Lowest In Early G1 |
| Alternative Antibody Names | Anti-Nucleoside Diphosphate Kinase Homolog 7 antibodyAnti-Ndk 7 antibodyAnti-Ndp Kinase Homolog 7 antibodyAnti-3'-5' Exonuclease Nme7 antibodyAnti-Protein Kinase Nme7 antibodyAnti-Nm23-H7 antibodyAnti-NME7 antibody |
Information sourced from Uniprot.org
