| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NLGN2 (15-180) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NLGN2 |
| Gene ID: |
57555 |
| Uniprot ID: |
NLGN2_HUMAN |
| Immunogen Region: |
15-180 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 15-180 of human NLGN2 (NP_065846.1). |
| Immunogen Sequence: |
QRGGGGPGGGAPGGPGLGLG SLGEERFPVVNTAYGRVRGV RRELNNEILGPVVQFLGVPY ATPPLGARRFQPPEAPASWP GVRNATTLPPACPQNLHGAL PAIMLPVWFTDNLEAAATYV QNQSEDCLYLNLYVPTEDGP LTKKRDEATLNPPDTDIRDP GKKPVM |
| Tissue Specificity | Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. |
| Function | Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. |
| Protein Name | Neuroligin-2 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPostsynaptic Cell MembranePresynaptic Cell MembraneDetected At Postsynaptic Membranes In BrainDetected At Dendritic Spines In Cultured NeuronsColocalizes With Gphn And Arhgef9 At Neuronal Cell MembranesLocalized At Presynaptic Membranes In RetinaColocalizes With Gabrg2 At Inhibitory Synapses In The Retina |
| Alternative Antibody Names | Anti-Neuroligin-2 antibodyAnti-NLGN2 antibodyAnti-KIAA1366 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
