• Western blot analysis of lysates from mouse kidney, using NLGN1 Rabbit polyclonal antibody (STJ118545) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 6min.

Anti-NLGN1 antibody (200-300) (STJ118545)

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STJ118545

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NLGN1 (200-300) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NLGN1
Gene ID: 22871
Uniprot ID: NLGN1_HUMAN
Immunogen Region: 200-300
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human NLGN1 (NP_055747.1).
Immunogen Sequence: YGNVIVITVNYRLGVLGFLS TGDQAAKGNYGLLDLIQALR WTSENIGFFGGDPLRITVFG SGAGGSCVNLLTLSHYSEGN RWSNSTKGLFQRAIAQSGTA L
Tissue Specificity Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells.
Function Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. The protein is involved in nervous system development.
Protein Name Neuroligin-1
Database Links Reactome: R-HSA-6794361
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Postsynaptic Density
Synaptic Cleft
Synaptic Cell Membrane
Enriched In Synaptic Plasma Membranes And Clustered In Synaptic Clefts And Postsynaptic Densities
Colocalized With Dlg4/Psd-95 And Grin1/Nmdar1
Alternative Antibody Names Anti-Neuroligin-1 antibody
Anti-NLGN1 antibody
Anti-KIAA1070 antibody

Information sourced from Uniprot.org

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