| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NKAP |
| Gene ID: | 79576 |
| Uniprot ID: | NKAP_HUMAN |
| Immunogen Region: | 1-130 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human NKAP (NP_078804.2). |
| Immunogen Sequence: | MAPVSGSRSPDREASGSGGR RRSSSKSPKPSKSARSPRGR RSRSHSCSRSGDRNGLTHQL GGLSQGSRNQSYRSRSRSRS RERPSAPRGIPFASASSSVY YGSYSRPYGSDKPWPSLLDK EREESLRQKR |
| Function | Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. |
| Protein Name | Nf-Kappa-B-Activating Protein |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nf-Kappa-B-Activating Protein antibodyAnti-NKAP antibody |
Information sourced from Uniprot.org