Anti-NGB antibody (1-100) (STJ116726)

SKU:
STJ116726

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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NGB (1-100) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NGB
Gene ID: 58157
Uniprot ID: NGB_HUMAN
Immunogen Region: 1-100
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human NGB (NP_067080.1).
Immunogen Sequence: MERPEPELIRQSWRAVSRSP LEHGTVLFARLFALEPDLLP LFQYNCRQFSSPEDCLSSPE FLDHIRKVMLVIDAAVTNVE DLSSLEEYLASLGRKHRAVG
Tissue Specificity Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus.
Post Translational Modifications A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO. Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity.
Function Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.
Protein Name Neuroglobin
Database Links Reactome: R-HSA-8981607
Cellular Localisation Perikaryon
Cytoplasm
Mitochondrion
Alternative Antibody Names Anti-Neuroglobin antibody
Anti-NGB antibody

Information sourced from Uniprot.org

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