| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NFATC2IP (290-360) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NFATC2IP |
| Gene ID: |
84901 |
| Uniprot ID: |
NF2IP_HUMAN |
| Immunogen Region: |
290-360 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 290-360 of human NFATC2IP (NP_116204.3). |
| Immunogen Sequence: |
VDHMATHLGVSPSRILLLFG ETELSPTATPRTLKLGVADI IDCVVLTSSPEATETSQQLQ LRVQGKEKHQT |
| Post Translational Modifications | Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production. |
| Function | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter.this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9. |
| Protein Name | Nfatc2-Interacting Protein45 Kda Nf-At-Interacting Protein45 Kda Nfat-Interacting ProteinNuclear Factor Of Activated T-Cells - Cytoplasmic 2-Interacting Protein |
| Cellular Localisation | NucleusCytoplasmTraf1 Is Associated With A Fraction Of Nfatc2ip In The Cytoplasm And Prevents Its Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Nfatc2-Interacting Protein antibodyAnti-45 Kda Nf-At-Interacting Protein antibodyAnti-45 Kda Nfat-Interacting Protein antibodyAnti-Nuclear Factor Of Activated T-Cells - Cytoplasmic 2-Interacting Protein antibodyAnti-NFATC2IP antibodyAnti-NIP45 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
