| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NEK1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NEK1 |
| Gene ID: |
4750 |
| Uniprot ID: |
NEK1_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human NEK1 (NP_036356.1). |
| Immunogen Sequence: |
MEKYVRLQKIGEGSFGKAIL VKSTEDGRQYVIKEINISRM SSKEREESRREVAVLANMKH PNIVQYRESFEENGSLYIVM DYCEGGDLFKRINAQKGVLF |
| Tissue Specificity | High fetal expression in the brain and kidney. |
| Function | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly. |
| Protein Name | Serine/Threonine-Protein Kinase Nek1Never In Mitosis A-Related Kinase 1Nima-Related Protein Kinase 1Renal Carcinoma Antigen Ny-Ren-55 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeAssociated With The Pericentriolar MaterialLocalizes To Centrosome During Interphase And MitosisTranslocated From Cytoplasm To Discrete Nuclear Foci At Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Nek1 antibodyAnti-Never In Mitosis A-Related Kinase 1 antibodyAnti-Nima-Related Protein Kinase 1 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-55 antibodyAnti-NEK1 antibodyAnti-KIAA1901 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
