| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Natural cytotoxicity triggering receptor 3 (104-153) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NCR3 |
| Gene ID: |
259197 |
| Uniprot ID: |
NCTR3_HUMAN |
| Immunogen Region: |
104-153 |
| Specificity: |
NKp30 Polyclonal Antibody detects endogenous levels of NKp30 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human NCR3. AA range:104-153 |
| Tissue Specificity | Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. |
| Function | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
| Protein Name | Natural Cytotoxicity Triggering Receptor 3Activating Natural Killer Receptor P30Natural Killer Cell P30-Related ProteinNk-P30Nkp30Cd Antigen Cd337 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Natural Cytotoxicity Triggering Receptor 3 antibodyAnti-Activating Natural Killer Receptor P30 antibodyAnti-Natural Killer Cell P30-Related Protein antibodyAnti-Nk-P30 antibodyAnti-Nkp30 antibodyAnti-Cd Antigen Cd337 antibodyAnti-NCR3 antibodyAnti-1C7 antibodyAnti-LY117 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
