| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NCEH1 (90-440) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NCEH1 |
| Gene ID: |
57552 |
| Uniprot ID: |
NCEH1_HUMAN |
| Immunogen Region: |
90-440 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 90-440 of human NCEH1 (NP_065843.3). |
| Immunogen Sequence: |
HLLALNFIIVSFGKKSAWSS AQVKVTDTDFDGVEVRVFEG PPKPEEPLKRSVVYIHGGGW ALASAKIRYYDELCTAMAEE LNAVIVSIEYRLVPKVYFPE QIHDVVRATKYFLKPEVLQK YMVDPGRICISGDSAGGNLA AALGQQFTQDASLKNKLKLQ ALIYPVLQALDFNTPSYQQN VNTPILPRYVMVKYWVDYFK GNYDFVQAMIVNNHTSLDVE EAAAVRARLNWTSLLPASF |
| Tissue Specificity | Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines. |
| Post Translational Modifications | N-glycosylated. |
| Function | Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration. |
| Protein Name | Neutral Cholesterol Ester Hydrolase 1NcehAcetylalkylglycerol Acetylhydrolase2-Acetyl Mage HydrolaseArylacetamide Deacetylase-Like 1 |
| Database Links | Reactome: R-HSA-8964038 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinMicrosome |
| Alternative Antibody Names | Anti-Neutral Cholesterol Ester Hydrolase 1 antibodyAnti-Nceh antibodyAnti-Acetylalkylglycerol Acetylhydrolase antibodyAnti-2-Acetyl Mage Hydrolase antibodyAnti-Arylacetamide Deacetylase-Like 1 antibodyAnti-NCEH1 antibodyAnti-AADACL1 antibodyAnti-KIAA1363 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
