| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MYOZ1 (180-299) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MYOZ1 |
| Gene ID: |
58529 |
| Uniprot ID: |
MYOZ1_HUMAN |
| Immunogen Region: |
180-299 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-299 of human MYOZ1 (NP_067068.1). |
| Immunogen Sequence: |
VFKTYISPWERAMGVDPQQK MELGIDLLAYGAKAELPKYK SFNRTAMPYGGYEKASKRMT FQMPKFDLGPLLSEPLVLYN QNLSNRPSFNRTPIPWLSSG EPVDYNVDIGIPLDGETEEL |
| Tissue Specificity | Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas. |
| Function | Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
| Protein Name | Myozenin-1Calsarcin-2Filamin- - Actinin- And Telethonin-Binding ProteinProtein Fatz |
| Cellular Localisation | NucleusCell ProjectionPseudopodiumLocalized To The Nucleus And Pseudopodia Of Undifferentiated Cells And Detected Throughout The Myotubes Of Differentiated CellsColocalizes With Actn2Flnc And Myot At The Z-Lines Of Skeletal Muscle |
| Alternative Antibody Names | Anti-Myozenin-1 antibodyAnti-Calsarcin-2 antibodyAnti-Filamin- - Actinin- And Telethonin-Binding Protein antibodyAnti-Protein Fatz antibodyAnti-MYOZ1 antibodyAnti-MYOZ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and NHEJ1 knockout (KO) HeLa cells, using [KO Validated] NHEJ1 Rabbit polyclonal antibody (STJ11103937) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/176582/367429/STJ11103937_1__73085.1713132967.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and NHEJ1 knockout (KO) HeLa cells, using [KO Validated] NHEJ1 Rabbit polyclonal antibody (STJ11103937) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.")