| Tissue Specificity | Expressed in the immune system. In the kidney, predominantly expressed in the glomerulus, including podocytes. |
| Function | Actin-based motor molecule with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. |
| Protein Name | Unconventional Myosin-IeMyosin-IcUnconventional Myosin 1e |
| Cellular Localisation | CytoplasmCytoskeletonCytoplasmic VesicleClathrin-Coated VesicleCell JunctionColocalizes With F-ActinIn Cultured PodocytesIt Localizes Close To And Is Associated With The Cytoplasmic MembraneWith Enrichment At The Lamellipodia TipsColocalizes With Cytoplasmic VesiclesIncluding Endocytic Clathrin-Coated VesiclesColocalizes With Dynamin At Cytoplasmic Vesicles |
| Alternative Antibody Names | Anti-Unconventional Myosin-Ie antibodyAnti-Myosin-Ic antibodyAnti-Unconventional Myosin 1e antibodyAnti-MYO1E antibodyAnti-MYO1C antibody |
Information sourced from Uniprot.org
