| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MYL12B (1-172) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MYL12B |
| Gene ID: |
103910/10627 |
| Uniprot ID: |
ML12B_HUMAN |
| Immunogen Region: |
1-172 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human MYL12B (NP_291024.1). |
| Immunogen Sequence: |
MSSKKAKTKTTKKRPQRATS NVFAMFDQSQIQEFKEAFNM IDQNRDGFIDKEDLHDMLAS LGKNPTDAYLDAMMNEAPGP INFTMFLTMFGEKLNGTDPE DVIRNAFACFDEEATGTIQE DYLRELLTTMGDRFTDEEVD ELYREAPIDKKGNFNYIEFT RILKHGAKDKDD |
| Tissue Specificity | Ubiquitously expressed in various hematopoietic cells. |
| Post Translational Modifications | Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment. |
| Function | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. |
| Protein Name | Myosin Regulatory Light Chain 12bMlc-2aMlc-2Myosin Regulatory Light Chain 2-B - Smooth Muscle IsoformMyosin Regulatory Light Chain 20 KdaMlc20Myosin Regulatory Light Chain Mrlc2Shujun-1 |
| Database Links | Reactome: R-HSA-3928663Reactome: R-HSA-416572Reactome: R-HSA-445355Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5627123 |
| Alternative Antibody Names | Anti-Myosin Regulatory Light Chain 12b antibodyAnti-Mlc-2a antibodyAnti-Mlc-2 antibodyAnti-Myosin Regulatory Light Chain 2-B - Smooth Muscle Isoform antibodyAnti-Myosin Regulatory Light Chain 20 Kda antibodyAnti-Mlc20 antibodyAnti-Myosin Regulatory Light Chain Mrlc2 antibodyAnti-Shujun-1 antibodyAnti-MYL12B antibodyAnti-MRLC2 antibodyAnti-MYLC2B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
