| Host: |
Mouse |
| Applications: |
WB/IF/IHC/IP |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Major Vault Protein is suitable for use in Western Blot, Immunofluorescence, Immunohistochemistry and Immunoprecipitation research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
1032 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1k |
| Formulation: |
PBS with 0.02% Sodium Azide. |
| Purification: |
Affinity purified from tissue culture. |
| Concentration: |
Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Dilution Range: |
Immunoblotting (1-2 µg/ml). Immunofluorescence (0, 5-1, 0 µg/ml). Immunohistology (1-2 µg/ml for 30-60 minutes at RT; staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by co |
| Storage Instruction: |
Store for up to 1 year at 2-8°C upon receipt. |
| Gene Symbol: |
MVP |
| Gene ID: |
9961 |
| Uniprot ID: |
MVP_HUMAN |
| Immunogen: |
A BALB/c mouse was immunized with affinity purified nuclear extract proteins. Fusion partner: Sp2/0-Ag14. |
| Tissue Specificity | Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. |
| Post Translational Modifications | Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11. |
| Function | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. |
| Protein Name | Major Vault ProteinMvpLung Resistance-Related Protein |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmNucleusNuclear Pore ComplexPerinuclear Region5% Found In The Nuclear Pore ComplexTranslocates From The Nucleus To The Cytoplasm Upon Egf Treatment |
| Alternative Antibody Names | Anti-Major Vault Protein antibodyAnti-Mvp antibodyAnti-Lung Resistance-Related Protein antibodyAnti-MVP antibodyAnti-LRP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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