| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MSH3 (617-761) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MSH3 |
| Gene ID: |
4437 |
| Uniprot ID: |
MSH3_HUMAN |
| Immunogen Region: |
617-761 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 617-761 of human MSH3 (NP_004696.2). |
| Immunogen Sequence: |
FNTSEEHHADMYRSDLPNPD TLSAELHCWRIKWKHRGKDI ELPSTIYEALHLPDIKFFPN VYALLKVLCILPVMKVENER YENGRKRLKAYLRNTLTDQR SSNLALLNINFDIKHDLDLM VDTYIKLYTSKSELPTDNSE TVENT |
| Function | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. |
| Protein Name | Dna Mismatch Repair Protein Msh3Hmsh3Divergent Upstream ProteinDupMismatch Repair Protein 1Mrp1 |
| Database Links | Reactome: R-HSA-5358606Reactome: R-HSA-5632927Reactome: R-HSA-5632928 |
| Alternative Antibody Names | Anti-Dna Mismatch Repair Protein Msh3 antibodyAnti-Hmsh3 antibodyAnti-Divergent Upstream Protein antibodyAnti-Dup antibodyAnti-Mismatch Repair Protein 1 antibodyAnti-Mrp1 antibodyAnti-MSH3 antibodyAnti-DUC1 antibodyAnti-DUG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
