| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
MRC2 |
| Gene ID: |
9902 |
| Uniprot ID: |
MRC2_HUMAN |
| Immunogen Region: |
35-513 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 35-513 of human MRC2 (NP_006030.2). |
| Immunogen Sequence: |
DAALPEPNVFLIFSHGLQGC LEAQGGQVRVTPACNTSLPA QRWKWVSRNRLFNLGTMQCL GTGWPGTNTTASLGMYECDR EALNLRWHCRTLGDQLSLLL GARTSNISKPGTLERGDQTR SGQWRIYGSEEDLCALPYHE VYTIQGNSHGKPCTIPFKYD NQWFHGCTSTGREDGHLWCA TTQDYGKDERWGFCPIKSND CETFWDKDQLTDSCYQFNFQ STLSWREAWASCEQQGADL |
| Tissue Specificity | Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. |
| Post Translational Modifications | N-glycosylated. |
| Function | May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). |
| Protein Name | C-Type Mannose Receptor 2C-Type Lectin Domain Family 13 Member EEndocytic Receptor 180Macrophage Mannose Receptor 2Urokinase-Type Plasminogen Activator Receptor-Associated ProteinUpar-Associated ProteinUrokinase Receptor-Associated ProteinCd Antigen Cd280 |
| Database Links | Reactome: R-HSA-1236978 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Mannose Receptor 2 antibodyAnti-C-Type Lectin Domain Family 13 Member E antibodyAnti-Endocytic Receptor 180 antibodyAnti-Macrophage Mannose Receptor 2 antibodyAnti-Urokinase-Type Plasminogen Activator Receptor-Associated Protein antibodyAnti-Upar-Associated Protein antibodyAnti-Urokinase Receptor-Associated Protein antibodyAnti-Cd Antigen Cd280 antibodyAnti-MRC2 antibodyAnti-CLEC13E antibodyAnti-ENDO180 antibodyAnti-KIAA0709 antibodyAnti-UPARAP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
