| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MORC2 (60-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MORC2 |
| Gene ID: |
22880 |
| Uniprot ID: |
MORC2_HUMAN |
| Immunogen Region: |
60-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human MORC2 (NP_055756.1). |
| Immunogen Sequence: |
EDTMTCLFLSRTFHEEEGID EVIVPLPTWNARTREPVTDN VEKFAIETELIYKYSPFRTE EEVMTQFMKIPGDSGTLVII FNLKLMDNGEPELDIISNPR DIQMAETSPEGTKPERRSFR AYAAVLYIDPRMRIFIHGHK VQTKRLSCCLYKPRMYKYTS SRFKTRAEQEVKKAEHVARI AEEKAREAESK |
| Tissue Specificity | Highly expressed in smooth muscle, pancreas and testis. |
| Post Translational Modifications | Phosphorylated by PAK1 at Ser-739 upon DNA damage. Phosphorylation is required for ATPase activity and recruitment to damaged chromatin. |
| Function | Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing. Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA. Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9. Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation. |
| Protein Name | Atpase Morc2Morc Family Cw-Type Zinc Finger Protein 2Zinc Finger Cw-Type Coiled-Coil Domain Protein 1 |
| Database Links | Reactome: R-HSA-75105 |
| Cellular Localisation | NucleusCytoplasmCytosolChromosomeNucleus MatrixMainly Located In The NucleusUpon Phosphorylation At Ser-739Recruited To Damaged Chromatin |
| Alternative Antibody Names | Anti-Atpase Morc2 antibodyAnti-Morc Family Cw-Type Zinc Finger Protein 2 antibodyAnti-Zinc Finger Cw-Type Coiled-Coil Domain Protein 1 antibodyAnti-MORC2 antibodyAnti-KIAA0852 antibodyAnti-ZCWCC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
