• Immunohistochemistry analysis of MMP17 in paraffin-embedded Mouse brain using MMP17 Rabbit polyclonal antibody (STJ24580) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of MMP17 in paraffin-embedded Human colon using MMP17 Rabbit polyclonal antibody (STJ24580) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of various lysates using MMP17 Rabbit polyclonal antibody (STJ24580) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-MMP17 antibody (265-565) (STJ24580)

SKU:
STJ24580

£112.50 - £524.50
Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MMP17
Gene ID: 4326
Uniprot ID: MMP17_HUMAN
Immunogen Region: 265-565
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 265-565 of human MMP17 (NP_057239.4).
Immunogen Sequence: IMRPYYQGPVGDPLRYGLPY EDKVRVWQLYGVRESVSPTA QPEEPPLLPEPPDNRSSAPP RKDVPHRCSTHFDAVAQIRG EAFFFKGKYFWRLTRDRHLV SLQPAQMHRFWRGLPLHLDS VDAVYERTSDHKIVFFKGDR YWVFKDNNVEEGYPRPVSDF SLPPGGIDAAFSWAHNDRTY FFKDQLYWRYDDHTRHMDPG YPAQSPLWRGVPSTLDDAMR WSDGASYFFRGQEYWKVLD
Tissue Specificity Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.
Post Translational Modifications The precursor is cleaved by a furin endopeptidase.
Function Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
Protein Name Matrix Metalloproteinase-17
Mmp-17
Membrane-Type Matrix Metalloproteinase 4
Mt-Mmp 4
Mtmmp4
Membrane-Type-4 Matrix Metalloproteinase
Mt4-Mmp
Mt4mmp
Database Links Reactome: R-HSA-1592389
Cellular Localisation Isoform Long: Cell Membrane
Lipid-Anchor
Gpi-Anchor
Extracellular Side
Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-Matrix Metalloproteinase-17 antibody
Anti-Mmp-17 antibody
Anti-Membrane-Type Matrix Metalloproteinase 4 antibody
Anti-Mt-Mmp 4 antibody
Anti-Mtmmp4 antibody
Anti-Membrane-Type-4 Matrix Metalloproteinase antibody
Anti-Mt4-Mmp antibody
Anti-Mt4mmp antibody
Anti-MMP17 antibody
Anti-MT4MMP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance