| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MLLT10 |
| Gene ID: | 8028 |
| Uniprot ID: | AF10_HUMAN |
| Immunogen Region: | 250-500 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human MLLT10 (NP_001182555.1). |
| Immunogen Sequence: | EPSPALVPSLTVTTEKTYTS TSNNSISGSLKRLEDTTARF TNANFQEVSAHTSSGKDVSE TRGSEGKGKKSSAHSSGQRG RKPGGGRNPGTTVSAASPFP QGSFSGTPGSVKSSSGSSVQ SPQDFLSFTDSDLRNDSYSH SQQSSATKDVHKGESGSQEG GVNSFSTLIGLPSTSAVTSQ PKSFENSPGDLGNSSLPTAG YKRAQTSGIEEETVKEKKRK GNKQSKHGPGRPKGNKNQE |
| Tissue Specificity | Expressed abundantly in testis. |
| Function | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation. |
| Protein Name | Protein Af-10All1-Fused Gene From Chromosome 10 Protein |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Af-10 antibodyAnti-All1-Fused Gene From Chromosome 10 Protein antibodyAnti-MLLT10 antibodyAnti-AF10 antibody |
Information sourced from Uniprot.org