| Tissue Specificity | Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine. |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. |
| Function | E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29. |
| Protein Name | Probable E3 Ubiquitin-Protein Ligase Mid2Midin-2Midline Defect 2Midline-2Ring Finger Protein 60Ring-Type E3 Ubiquitin Transferase Mid2Tripartite Motif-Containing Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule-Associated |
| Alternative Antibody Names | Anti-Probable E3 Ubiquitin-Protein Ligase Mid2 antibodyAnti-Midin-2 antibodyAnti-Midline Defect 2 antibodyAnti-Midline-2 antibodyAnti-Ring Finger Protein 60 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mid2 antibodyAnti-Tripartite Motif-Containing Protein 1 antibodyAnti-MID2 antibodyAnti-FXY2 antibodyAnti-RNF60 antibodyAnti-TRIM1 antibody |
Information sourced from Uniprot.org
