| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MESDC2 (1-234) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MESD |
| Gene ID: |
23184 |
| Uniprot ID: |
MESD_HUMAN |
| Immunogen Region: |
1-234 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human MESDC2 (NP_055969.1). |
| Immunogen Sequence: |
MAASRWARKAVVLLCASDLL LLLLLLPPPGSCAAEGSPGT PDESTPPPRKKKKDIRDYND ADMARLLEQWEKDDDIEEGD LPEHKRPSAPVDFSKIDPSK PESILKMTKKGKTLMMFVTV SGSPTEKETEEITSLWQGSL FNANYDVQRFIVGSDRAIFM LRDGSYAWEIKDFLVGQDRC ADVTLEGQVYPGKGGGSKEK NKTKQDKGKKKKEGDLKSRS SKEENRAGNKREDL |
| Function | Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells. |
| Protein Name | Lrp Chaperone MesdLdlr Chaperone MesdMesoderm Development Lrp Chaperone MesdMesoderm Development Candidate 2Mesoderm Development ProteinRenal Carcinoma Antigen Ny-Ren-61 |
| Cellular Localisation | Endoplasmic ReticulumReleased From Apoptotic Cells And Shed Photoreceptor Outer Segments |
| Alternative Antibody Names | Anti-Lrp Chaperone Mesd antibodyAnti-Ldlr Chaperone Mesd antibodyAnti-Mesoderm Development Lrp Chaperone Mesd antibodyAnti-Mesoderm Development Candidate 2 antibodyAnti-Mesoderm Development Protein antibodyAnti-Renal Carcinoma Antigen Ny-Ren-61 antibodyAnti-MESD antibodyAnti-KIAA0081 antibodyAnti-MESDC2 antibodyAnti-MESDM antibodyAnti-UNQ1911 antibodyAnti-PRO4369 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
