| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MEN1 |
| Gene ID: | 4221 |
| Uniprot ID: | MEN1_HUMAN |
| Immunogen Region: | 516-615 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 516-615 of human Menin (O00255). |
| Immunogen Sequence: | VSGPPRKPPGTVAGTARGPE GGSTAQVPAPTASPPPEGPV LTFQSEKMKGMKELLVATKI NSSAIKLQLTAQSQVQMKKQ KVSTPSDYTLSFLKRQRKGL |
| Tissue Specificity | Ubiquitous. |
| Function | Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. |
| Protein Name | Menin |
| Database Links | Reactome: R-HSA-201722 Reactome: R-HSA-2173796 Reactome: R-HSA-3769402 Reactome: R-HSA-381426 Reactome: R-HSA-5626467 Reactome: R-HSA-8957275 Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus Concentrated In Nuclear Body-Like Structures Relocates To The Nuclear Matrix Upon Gamma Irradiation |
| Alternative Antibody Names | Anti-Menin antibody Anti-MEN1 antibody Anti-SCG2 antibody |
Information sourced from Uniprot.org