| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MCTS1 |
| Gene ID: |
28985 |
| Uniprot ID: |
MCTS1_HUMAN |
| Immunogen Region: |
1-181 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human MCTS1 (NP_054779.1). |
| Immunogen Sequence: |
MFKKFDEKENVSNCIQLKTS VIKGIKNQLIEQFPGIEPWL NQIMPKKDPVKIVRCHEHIE ILTVNGELLFFRQREGPFYP TLRLLHKYPFILPHQQVDKG AIKFVLSGANIMCPGLTSPG AKLYPAAVDTIVAIMAEGKQ HALCVGVMKMSAEDIEKVNK GIGIENIHYLNDGLWHMKTY K |
| Tissue Specificity | Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas. |
| Post Translational Modifications | Phosphorylation is critical for stabilization and promotion of cell proliferation. |
| Function | Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair. Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2. |
| Protein Name | Malignant T-Cell-Amplified Sequence 1Mct-1Multiple Copies T-Cell Malignancies |
| Cellular Localisation | CytoplasmNuclear Relocalization After Dna Damage |
| Alternative Antibody Names | Anti-Malignant T-Cell-Amplified Sequence 1 antibodyAnti-Mct-1 antibodyAnti-Multiple Copies T-Cell Malignancies antibodyAnti-MCTS1 antibodyAnti-MCT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
