| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MCTS1 (1-181) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MCTS1 |
| Gene ID: |
28985 |
| Uniprot ID: |
MCTS1_HUMAN |
| Immunogen Region: |
1-181 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human MCTS1 (NP_054779.1). |
| Immunogen Sequence: |
MFKKFDEKENVSNCIQLKTS VIKGIKNQLIEQFPGIEPWL NQIMPKKDPVKIVRCHEHIE ILTVNGELLFFRQREGPFYP TLRLLHKYPFILPHQQVDKG AIKFVLSGANIMCPGLTSPG AKLYPAAVDTIVAIMAEGKQ HALCVGVMKMSAEDIEKVNK GIGIENIHYLNDGLWHMKTY K |
| Post Translational Modifications | Phosphorylation is critical for stabilization and promotion of cell proliferation. |
| Function | Anti-oncogene that plays a role in cell cycle regulation.decreases cell doubling time and anchorage-dependent growth.shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation.promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer.recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile.up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway.increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell.Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation.promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. |
| Protein Name | Malignant T-Cell-Amplified Sequence 1Mct-1Multiple Copies T-Cell Malignancies |
| Cellular Localisation | CytoplasmNuclear Relocalization After Dna Damage |
| Alternative Antibody Names | Anti-Malignant T-Cell-Amplified Sequence 1 antibodyAnti-Mct-1 antibodyAnti-Multiple Copies T-Cell Malignancies antibodyAnti-MCTS1 antibodyAnti-MCT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
