| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MARCH6 (10-80) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MARCHF6 |
| Gene ID: |
10299 |
| Uniprot ID: |
MARH6_HUMAN |
| Immunogen Region: |
10-80 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 10-80 of human MARCH6 (NP_005876.2). |
| Immunogen Sequence: |
RVCRSEGTPEKPLYHPCVCT GSIKFIHQECLVQWLKHSRK EYCELCKHRFAFTPIYSPDM PSRLPIQDIFA |
| Tissue Specificity | Present in brain (at protein level). |
| Post Translational Modifications | Auto-ubiquitinated, which results in proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Marchf6Doa10 HomologMembrane-Associated Ring Finger Protein 6Membrane-Associated Ring-Ch Protein ViMarch-ViProtein Teb-4Ring Finger Protein 176Ring-Type E3 Ubiquitin Transferase Marchf6 |
| Database Links | Reactome: R-HSA-901032 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Marchf6 antibodyAnti-Doa10 Homolog antibodyAnti-Membrane-Associated Ring Finger Protein 6 antibodyAnti-Membrane-Associated Ring-Ch Protein Vi antibodyAnti-March-Vi antibodyAnti-Protein Teb-4 antibodyAnti-Ring Finger Protein 176 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Marchf6 antibodyAnti-MARCHF6 antibodyAnti-KIAA0597 antibodyAnti-MARCH6 antibodyAnti-RNF176 antibodyAnti-TEB4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
