| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAP3K12 (1-210) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAP3K12 |
| Gene ID: |
7786 |
| Uniprot ID: |
M3K12_HUMAN |
| Immunogen Region: |
1-210 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human MAP3K12 (NP_001180440.1). |
| Immunogen Sequence: |
MACLHETRTPSPSFGGFVST LSEASMRKLDPDTSDCTPEK DLTPTQCVLRDVVPLGGQGG GGPSPSPGGEPPPEPFANSV LQLHEQDAGGPGGAAGSPES RASRVRADEVRLQCQSGSGF LEGLFGCLRPVWTMIGKAYS TEHKQQQEDLWEVPFEEILD LQWVGSGAQGAVFLGRFHGE EVAVKKVRDLKETDIKHLRK LKHPNIITFK |
| Tissue Specificity | Highly expressed in brain and kidney. |
| Post Translational Modifications | Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation. |
| Function | Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 12Dual Leucine Zipper Bearing KinaseDlkLeucine-Zipper Protein KinaseZpkMapk-Upstream KinaseMukMixed Lineage Kinase |
| Cellular Localisation | CytoplasmCell MembraneBehaves Essentially As An Integral Membrane Protein |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 12 antibodyAnti-Dual Leucine Zipper Bearing Kinase antibodyAnti-Dlk antibodyAnti-Leucine-Zipper Protein Kinase antibodyAnti-Zpk antibodyAnti-Mapk-Upstream Kinase antibodyAnti-Muk antibodyAnti-Mixed Lineage Kinase antibodyAnti-MAP3K12 antibodyAnti-ZPK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
