| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAGI3 (1-105) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAGI3 |
| Gene ID: |
260425 |
| Uniprot ID: |
MAGI3_HUMAN |
| Immunogen Region: |
1-105 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human MAGI3 (NP_001136254.1). |
| Immunogen Sequence: |
MSKTLKKKKHWLSKVQECAV SWAGPPGDFGAEIRGGAERG EFPYLGRLREEPGGGTCCVV SGKAPSPGDVLLEVNGTPVS GLTNRDTLAVIRHFREPIRL KTVKP |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex. |
| Function | Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. |
| Protein Name | Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 3Membrane-Associated Guanylate Kinase Inverted 3Magi-3 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCell JunctionTight JunctionNucleusConcentrates In Specific Sites At The Plasma Membrane And In The NucleusIn Epithelial CellsIt Localizes At Tight Junctions |
| Alternative Antibody Names | Anti-Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 3 antibodyAnti-Membrane-Associated Guanylate Kinase Inverted 3 antibodyAnti-Magi-3 antibodyAnti-MAGI3 antibodyAnti-KIAA1634 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
