| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAFG (1-162) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAFG |
| Gene ID: |
4097 |
| Uniprot ID: |
MAFG_HUMAN |
| Immunogen Region: |
1-162 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-162 of human MAFG (NP_002350.1). |
| Immunogen Sequence: |
MTTPNKGNKALKVKREPGEN GTSLTDEELVTMSVRELNQH LRGLSKEEIVQLKQRRRTLK NRGYAASCRVKRVTQKEELE KQKAELQQEVEKLASENASM KLELDALRSKYEALQTFART VARSPVAPARGPLAAGLGPL VPGKVAATSVITIVKSKTDA RS |
| Tissue Specificity | Highly expressed in skeletal muscle. Also expressed in heart and brain. |
| Post Translational Modifications | Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2. Sumoylation at Lys-14 is required for active transcriptional repression. |
| Function | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin gene expression when associated with NFE2L2. May be involved in signal transduction of extracellular H(+). |
| Protein Name | Transcription Factor MafgV-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog GHmaf |
| Database Links | Reactome: R-HSA-9759194Reactome: R-HSA-9818028Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Mafg antibodyAnti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog G antibodyAnti-Hmaf antibodyAnti-MAFG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
